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Ketamine FAQ

Ketamine is an FDA-approved anesthetic agent developed in the 1960’s. It has been used primarily as a general anesthetic in surgery for adults, children, and animals. Ketamine has an incredibly safe record. In recent years, research has shown that Ketamine can be highly effective in treating Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD), PTSD, and other mood disorders.

Research studies show that intravenous infusions of Ketamine can be effective for 60-80% of individuals experiencing depressive symptoms. Ketamine can typically prevent depressive symptoms for several weeks; however, some patients experience remission from depression for months.

No, your psychiatrist, psychologist, other licensed mental health provider, or any other physician can refer you.

The exact process that allows ketamine to alleviate depression is complex and research is ongoing. It is known that ketamine works on a neurotransmitter called Glutamate which leads to the production of an essential growth factor that prompts the brain to repair neurons that have been damaged mental health illnesses, including stress. Because of this process, Ketamine can quickly improve mood while facilitating the regeneration of neurons.

IV Ketamine therapy is contraindicated for patients diagnosed with psychosis. If you have hypertension, cardiac, or pulmonary conditions, you may be required to be medically cleared before starting IV Ketamine therapy.

You should avoid all solid foods and milk for 6 hours before your Ketamine infusion. Clear liquids such as water, sodas, pulpless fruit juices, tea, and black coffee can be consumed up to 2 hours before treatment begins. You should absolutely avoid alcohol, sedatives, or the use of any illicit substances. Alcohol, sedatives, and illicit drugs are extremely dangerous when combined with ketamine.

The Ketamine will be infused intravenously slowly over 45 minutes. Initially, you may not experience any noticeable effects, but as the treatment progresses, you may experience a feeling of euphoria or “weightlessness”. Most patients describe mild symptoms of disconnection and lack of continuity between thoughts, memories, surroundings, actions and identity which are generally well tolerated. You will be monitored throughout the treatment and we are prepared to treat any unpleasant side effects during the therapy. Within 15 minutes prior to completing the treatment, you will to begin to regain your senses and your cognition will return to normal.

Typically, the effects of a single dose of Ketamine can last up to two weeks. At the completion of a series of six treatments, some people remain asymptomatic for several months. Booster infusions may also be a treatment option, which can be provided monthly or a few times per year as deemed appropriate by the physician.

A typical treatment course consists of a total of six infusions, and it is recommended that the infusions are completed within a 3 week period to maximize the effects of Ketamine. The repair and growth of neurons can lead to long lasting remission in depressive symptoms. However, the treatment course depends on each patient’s specific circumstances.

IV Ketamine therapy is not currently covered by insurance. However, you may discuss payment options with your provider or an authorized Indy Advanced Therapeutics staff member.

IV Ketamine therapy is not currently covered by insurance. However, you may discuss payment options with your provider or an authorized Indy Advanced Therapeutics staff member.

Yes, IV Ketamine therapy is an outpatient treatment and you will be able to leave at the completion of your treatment, but you are required to have someone drive you.

When Ketamine is administered by a professional for the treatment of depression, it does not appear to be addictive. Research indicates that when Ketamine is administered in a clinical setting, patients are safe and protected from the potential of addition.